An exact Cochran-Armitage test for trend when dose-response shapes are a priori unknown

verfasst von

Markus Neuhäuser, Ludwig A. Hothorn

Abstract

The Cochran-Armitage test is a widely used test for trend among binomial proportions of a dose-response relationship. This test requires preassigned fixed dose scores. Equally spaced scores were usually suggested if the dose-dependent shape of the binomial proportions is a priori unknown. Another approach is the construction of a maximin efficiency robust test. We recommend a combination of Cochran-Armitage tests based on different scores and the use of the maximum of the test statistics for a new test. Simulation results suggest that this combined test is superior to both the single test with equally spaced scores and the maximin efficiency robust test. The methods are applied to data of a toxicity and a tumorigenicity study with a stratified design.

Organisationseinheit(en)

Abteilung Biostatistik

Externe Organisation(en)

Altana Pharma

Typ

Artikel

Journal

Computational Statistics and Data Analysis

Band

30

Seiten

403-412

Anzahl der Seiten

10

ISSN

0167-9473

Publikationsdatum

07.07.1999

Publikationsstatus

Elektronisch veröffentlicht (E-Pub)

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Statistik und Wahrscheinlichkeit, Computational Mathematics, Theoretische Informatik und Mathematik, Angewandte Mathematik

Elektronische Version(en)

https://doi.org/10.1016/S0167-9473(98)00091-7 (Zugang: Geschlossen)