Towards Small Scale

Overview and Applications of Microfluidics in Biotechnology

verfasst von: Anton Enders, Alexander Grünberger, Janina Bahnemann
Abstract: Thanks to recent and continuing technological innovations, modern microfluidic systems are increasingly offering researchers working across all fields of biotechnology exciting new possibilities (especially with respect to facilitating high throughput analysis, portability, and parallelization). The advantages offered by microfluidic devices—namely, the substantially lowered chemical and sample consumption they require, the increased energy and mass transfer they offer, and their comparatively small size—can potentially be leveraged in every sub-field of biotechnology. However, to date, most of the reported devices have been deployed in furtherance of healthcare, pharmaceutical, and/or industrial applications. In this review, we consider examples of microfluidic and miniaturized systems across biotechnology sub-fields. In this context, we point out the advantages of microfluidics for various applications and highlight the common features of devices and the potential for transferability to other application areas. This will provide incentives for increased collaboration between researchers from different disciplines in the field of biotechnology.
Organisationseinheit(en): Institut für Technische Chemie
Externe Organisation(en): Karlsruher Institut für Technologie (KIT)
Universität Augsburg
Typ: Übersichtsarbeit
Journal: Molecular Biotechnology
Band: 66
Seiten: 365-377
Anzahl der Seiten: 13
ISSN: 1073-6085
Publikationsdatum: 03.2024
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Biotechnologie, Bioengineering, Biochemie, Angewandte Mikrobiologie und Biotechnologie, Molekularbiologie
Elektronische Version(en): https://doi.org/10.1007/s12033-022-00626-6 (Zugang: Offen)

BibTeX

@article{5bd64dd64f9e4f7c8f9b782b454f9ed8,
title = "Towards Small Scale: Overview and Applications of Microfluidics in Biotechnology",
abstract = "Thanks to recent and continuing technological innovations, modern microfluidic systems are increasingly offering researchers working across all fields of biotechnology exciting new possibilities (especially with respect to facilitating high throughput analysis, portability, and parallelization). The advantages offered by microfluidic devices—namely, the substantially lowered chemical and sample consumption they require, the increased energy and mass transfer they offer, and their comparatively small size—can potentially be leveraged in every sub-field of biotechnology. However, to date, most of the reported devices have been deployed in furtherance of healthcare, pharmaceutical, and/or industrial applications. In this review, we consider examples of microfluidic and miniaturized systems across biotechnology sub-fields. In this context, we point out the advantages of microfluidics for various applications and highlight the common features of devices and the potential for transferability to other application areas. This will provide incentives for increased collaboration between researchers from different disciplines in the field of biotechnology.",
keywords = "Biochemical engineering, Industrial biotechnology, Lab-on-a-chip, Medical biotechnology, Microfluidic screening, Microfluidics, Nanofluidics, Organ-on-a-chip, Point-of-care, Point-of-use",
author = "Anton Enders and Alexander Gr{\"u}nberger and Janina Bahnemann",
note = "Funding Information: This research was supported by the NIH grants P01AG043352 and R01AG046860. Open Access funding enabled and organized by Projekt DEAL. Funding was provided by German Research Foundation (DFG) (Grant No. 346772917 Emmy Noether Programme). ",
year = "2024",
month = mar,
doi = "10.1007/s12033-022-00626-6",
language = "English",
volume = "66",
pages = "365--377",
journal = "Molecular Biotechnology",
issn = "1073-6085",
publisher = "Humana Press",
number = "3",
}